San Francisco
The most cosmopolitan and trendy district
San Francisco is the city's most vibrant and cosmopolitan neighborhood, home to international restaurants, craft cocktail bars, art galleries, and sophisticated nightlife. Uruguay Street and 50th Street are gastronomic epicenters where you'll find everything from creative sushi to Argentine steakhouses. It's the perfect neighborhood for food lovers and Panama's nightlife.
Practical Information
Our Tip
Book dinner on Uruguay Street or 50th Street, then walk or drive 10–15 minutes to the Cinta Costera in Punta Paitilla for sunset — the bayfront is not inside San Francisco proper, but it is a short hop away.
Frequently Asked Questions
How are San Francisco and UpTown related?
UpTown is Empresas Bern's mixed-use project on Uruguay Street, within San Francisco/Bella Vista's dining corridor. Spongi's Condo Suites will sit on that axis between nightlife and Obarrio.
Is San Francisco on the waterfront?
No — it is an inland dining and nightlife corridor. The bayfront is in Punta Paitilla (5–10 min by car); MOVA in Obarrio shows the financial district, not this waterfront.
More in Panama City

Casco Viejo
UNESCO Casco Viejo: colonial plazas, rooftop bars, National Theater & dining. Spongi guide + city…

Coco del Mar
Coco del Mar: Omar Park, dining & Dovle apartments with Itodo Bistro. Premium residential…

Punta Paitilla
Punta Paitilla guide: Pacific bayfront, marina, Multiplaza & sunset skyline. How it differs from…
Obarrio
Obarrio guide: financial district, SOHO Mall, MOVA B&B Italia & fine dining. The bayfront is Punta…
Costa del Este
Costa del Este: modern district, Town Center, BIOMA tower (61 levels) & 20 min to Tocumen Airport.…

UpTown — Uruguay Street
UpTown Uruguay Street: hotel-licensed Condo Suites, Roche Bobois & dining hub. Coming soon on…
Amador Causeway
Amador Causeway: Biomuseo, Panama Canal, Cavarosa & Nayamara towers. Spongi neighborhood guide.
Cinta Costera
Cinta Costera: 8 km bayfront promenade, skyline sunsets & access from Paitilla, Casco & Spongi…
Ready for your next adventure?
Book your luxury beachfront stay in Panama and create unforgettable memories.